| 翻訳と辞書 |
| EML4-ALK positive lung cancer ： ウィキペディア英語版 |
EML4-ALK positive lung cancer
EML4-ALK positive lung cancer is a medical term that refers to a primary malignant lung tumor whose cells contain a characteristic abnormal configuration of DNA wherein the ''echinoderm microtubule-associated protein-like 4'' (''EML4'') gene is fused to the ''anaplastic lymphoma kinase'' (''ALK'') gene. This abnormal gene fusion leads to the production of a protein (EML4-ALK) that appears, in many cases, to promote and maintain the malignant behavior of the cancer cells.
The transforming ''EML4-ALK'' fusion gene was first reported in non-small cell lung carcinoma (NSCLC) in 2007.
==Classification==
Most lung carcinomas containing the ''EML4-ALK'' gene fusion are adenocarcinomas.
Some studies suggest that the papillary adenocarcinoma and the signet ring cell adenocarcinoma variants are more likely to carry this fused gene than other histological variants.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「EML4-ALK positive lung cancer」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|